Development And Preclinical Validation Of New Therapeutic Approaches For Brain Tumors Bardi

Development And Preclinical Validation Of New Therapeutic Approaches For Brain Tumors
Bardi
Emilia Romagna, Bardi

Organisation/Company: Università di PaviaResearch Field: Neurosciences, Pharmacological sciences, Biological sciencesResearcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)Country: ItalyApplication Deadline: 22 Jan 2025 - 23:59 (UTC)Type of Contract: To be definedJob Status: Not ApplicableIs the job funded through the EU Research Framework Programme?

Not funded by a EU programmeIs the Job related to staff position within a Research Infrastructure?

NoOffer DescriptionThe project aims to validate new therapeutic approaches for the treatment of high-grade gliomas, including chemoresistant glioblastomas.

To achieve this objective, preclinical models of mice and rats will be developed using patient-derived cells.

The following will be validated: new advanced imaging approaches (MRI) to monitor tumor cell invasiveness and alterations in the tumor microenvironment, the biodistribution of new tracers to identify cells responsible for recurrence, and the efficacy of multivalent drugs that modulate the immune response and counteract tumor progression.

The research will be conducted according to Good Laboratory Practices (GLP) principles and will include methodologies such as flow cytometry, optical and confocal microscopy, MRI/confocal correlative microscopy, immunohistological analyses, and biomarker analyses in biofluids using ELISA. Main RequirementsDegree (with a course duration of not less than 4 years, as referred to in the pre-existing academic regulations pursuant to D. M.

n. 509/1999) or post-graduate degrees (pursuant to D. M.

n. 509/1999 and to n. 270/2004) awarded by Italian or foreign Universities recognized as equivalent - for the purposes of establishing the equivalence, candidates must provide the necessary documentation to enable the evaluating board to proceed with the qualification assessment. Scientific or professional curriculum suitable for conducting the research activity. If available, any Ph. D. title (Art 2- par.

1). Further Specific Assessable QualificationsMaster#39;s degree in biology and having carried out a thesis on a topic related to the area of neurobiology with the application of key techniques for the project in question. Skills in confocal microscopy and image analysis. Familiarity with immunocytochemistry methods, and immunohistochemistry on histological preparations. Selection ProcessThe application for admission to the selection procedure (dated and signed), the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page: https://pica. cineca. it/unipv by choosing the "Assegni di ricerca" item and selecting the Competition Notice you have chosen.

In order to register with the system, you must have an email address.

Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic. PDF format.

The selection of candidates is carried out on the basis of qualifications, project and interview, supplemented by a test of knowledge of the foreign language (Art.

6 – par.

1).

#J-18808-Ljbffr