Lab Technician/Research Assistant - Sr-Tiget Milano

Lab Technician/Research Assistant - Sr-Tiget
Milano
Lombardia, Milano

IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a Lab Technician/Research Assistant to join the Process Development Lab (PDL), Hematopoietic Cell Engineering Area, led by Marina Radrizzani at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), to work in projects focused on genetic engineering of T lymphocytes and hematopoietic stem cells (HSC).

SR-Tiget was created in 1996 as a joint-venture between Fondazione Telethon and Ospedale San Raffaele (OSR), with the mission to perform cutting edge research on gene and cell therapy and to translate its results into therapeutic advances for genetic diseases.

The Institute is located within the OSR campus, which includes a large multi-disciplinary research hospital, a biomedical research center, a university and also hosts several biotechnologies companies.

Over the years, SR-Tiget has given a pioneering contribution to the gene and cell therapy field with relevant discoveries in vector design, gene transfer and gene editing strategies, stem cell biology, identity and mechanism of action of regulatory cells in immune responses and innate immune cells in cancer.

SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials, which have already treated>120 patients and led to the filing and approval of 2 novel advanced therapy medicines.

**Main activities**:

Isolation, culture and genetic modification of T lymphocytes and HSC (lentiviral vector transduction, gene editing);

Process scale-up and standardization;

Cell-based assays, molecular assays, flow cytometry analyses;

Preparation of standard lab procedures and protocols;

General lab support.

**Who we are looking for**:

Bachelor or Master Degree (Biomedical Laboratory Technician, Biology, Biotechnology or equivalent) with strong lab wet experience;

High motivation to work in the field of Advanced Therapy Medicinal Products (ATMP);

High accuracy, reliability, precision;

Friendly, collaborative, pro-active mindset;

Good oral and written English;

Experience in Good Manufacturing Practices, automated cell manipulation systems and/or ATMP as a plus.

**Work details**:

**Type of contract**: collaboration;

**Duration**: one year, renewable;

**Place of work**: IRCCS San Raffaele Scientific Institute, SR-Tiget, via Olgettina 60, Milan, Italy.