Posdoctoral Position In The Field Of Immunity And Tissue Remodelling At University Of Milano Bi... Milano

Posdoctoral Position In The Field Of Immunity And Tissue Remodelling At University Of Milano Bi...
Milano
Lombardia, Milano

Organisation/Company: Università degli Studi di Milano-BicoccaDepartment: School of Medicine and SurgeryResearch Field: Biological sciences » BiologyResearcher Profile: Recognised Researcher (R2)Positions: Postdoc PositionsCountry: ItalyApplication Deadline: 28 Feb 2025 - 00:00 (UTC)Type of Contract: TemporaryJob Status: Full-timeHours Per Week: 35Offer Starting Date: 1 Apr 2025Is the job funded through the EU Research Framework Programme?

Not funded by a EU programmeIs the Job related to staff position within a Research Infrastructure?

NoOffer Description The research group led by Prof. Silvia Brunelli at the School of Medicine and Surgery, University of Milano-Bicocca, is seeking a highly motivated Post-Doctoral Research Fellow to join an exciting and ambitious project funded by Fondazione Telethon. Project Title: "Exploring the Role of SPP1 in Macrophage-Osteogenic Cell Crosstalk and its Involvement in Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva"Project Overview: Fibrodysplasia Ossificans Progressiva (FOP) is a rare congenital disorder characterized by abnormal bone formation (heterotopic ossification, HO) in ligaments, tendons, and skeletal muscles.

FOP is caused by gain-of-function mutations in the ACVR1 gene, which dysregulate the bone morphogenetic protein (BMP) signaling pathway.

While significant progress has been made in understanding the disease, the role of immune cells in HO remains controversial.

This research aims to investigate the hypothesis that, upon trauma, macrophages (MPs) infiltrating FOP lesions exhibit an altered metabolic signature, leading to an intermediate phenotype that secretes various factors, including SPP1 (osteopontin).

This, in turn, may accelerate the differentiation of mutant osteogenic precursors.

The findings of this study are expected to provide critical insights into the underlying mechanisms of FOP and potentially pave the way for new therapeutic strategies. Methodologies: The project will take advantage of a transgenic murine model of FOP and incorporate state-of-the-art techniques, including CRISPR/Cas9-based genome editing, genome-wide transcriptomic analysis, and in vitro and in vivo assays. Where to apply E-mail: ****** Research Field: Biological sciences » BiologyEducation Level: PhD or equivalentResearch Field: Medical sciences » OtherEducation Level: PhD or equivalentSkills/Qualifications:Experience in cell and molecular biologyExpertise in murine modelsProficiency in bioinformatics and data analysis (including R programming)Familiarity with any of the above-mentioned techniques will be considered an advantageLanguages: ENGLISH Level GoodYears of Research Experience: 1 - 4Additional Information Duration: 1 year (renewable for an additional year)Research Environment: The School of Medicine and Surgery at the University of Milano-Bicocca is located within the BioMedical Campus of Monza.

It consistently ranks among the top medical universities in Italy and has received the prestigious "Department of Excellence" financial award in 2018 and 2023.

The department offers a dynamic and stimulating environment, with access to cutting-edge research facilities. Eligibility criteria:Candidate Profile:We are looking for highly motivated researchers with a PhD in Biology, Biotechnology, Biomedical Sciences, or related fields, or equivalent qualification. A cover letter describing research interests and experience. Contact details of at least two referees. Work Location(s) Number of offers available: 1Company/Institute: School of Medicine and Surgery, University of Milano-BicoccaCountry: ItalyState/Province: MBCity: MonzaPostal Code: 20900Street: via Cadore 48#J-18808-Ljbffr