Post-Doctoral Position At Sr-Tiget Milano

Post-Doctoral Position At Sr-Tiget
Milano
Lombardia, Milano

IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a post-doctoral fellow to join the Retrovirus-Host Interactions and Innate Immunity to Gene Transfer Lab, led by Anna Kajaste-Rudnitski, PhD.

**Main activities**:

Aberrant sensing of nucleic acids originating from the expression of endogenous retroviral elements or accumulating DNA damage and consequent increase in type I IFN levels have been suggested to be a primary driver of pathogenesis of the Aicardi-Goutières Syndrome (AGS), a genetic Leukodystrophy that mainly affects the brain, immune system and skin.

Nevertheless, the precise molecular mechanisms triggering the disease remain elusive.

On these premises, we are recruiting a post-doctoral fellow with strong experience in iPSC-based differentiation of Neural Stem Cells and Progenitor and/or innate immunity to viral infections to work on a project aimed at evaluating the consequences of the AGS gene defects in the human Central Nervous Systems (CNS) taking advantage of iPSC-based in vitro differentiations.

The goal is to elucidate the role of different cell types of the CNS, including microglia, in AGS and to investigate what are the endogenous signals that aberrantly activate the disease-causing antiviral responses in these cells.

We combine molecular virology approaches with state-of-the-art NGS technology and proteomics in the highly relevant context of human iPSC-based in vitro disease models.

**Who we are looking for**:

**Work details**:

- Type of contract: Project-based Co. co. co with competitive salary negotiated based on experience;

- Duration: 3 years renewable;

- Place of work: San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.