Postdoc In Computational Biology - Giustacchini Group - Funded By Airc Milano

Postdoc In Computational Biology - Giustacchini Group - Funded By Airc
Milano
Lombardia, Milano

APPLICATION CLOSING DATE: February 9th, 2025

**Human Technopole (HT)**is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health.

HT is composed of five Centres: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science.

The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

**About the lab**:

Dr Alice Giustacchini's research group combines experimental and computational biology in a collaborative environment at Human Technopole (HT), utilizing state-of-the-art technologies and interdisciplinary expertise.

The group collaborates closely with clinical teams at UCL and Ospedale Pediatrico Bambino Gesù, connecting basic science with clinical practice to ensure translational impact.

By addressing key challenges in hematologic malignancies, the group aims to drive advancements in precision medicine and develop innovative approaches to improve therapeutic outcomes.

The Giustacchini Lab, part of the Population and Medical Genomics Centre at HT, is seeking a **postdoctoral researcher in computational biology** to investigate **the cellular and molecular dynamics of CAR T-cell therapy in blood cancers, funded by AIRC foundation for cancer research.

**Key Responsibilities

- Develop and implement **computational models** to study interactions between therapeutic cells, tumour cells, and normal hematopoietic cells.

- Analyse multiomics datasets, including **single-cell RNA-seq, ATAC-seq**, and clinical data, to understand therapy dynamics and resistance mechanisms.

- Integrate modelling approaches with experimental data to predict therapeutic outcomes and refine treatment strategies.

- Contribute to the preparation of high-quality, reproducible research outputs for publication in leading journals and conferences.

**Mandatory requirements**:

- PhD in computational biology, bioinformatics, mathematics, statistics or related disciplines.

- Strong programming skills (e. g. , R, Python) and proficiency in analysing high-dimensional single-cell datasets.

- Expertise in mathematical or computational modelling of biological systems.

- Fluency in English - HT is an international research institute

**Preferred requirements**:

- Familiarity with CAR T cell therapy or other cellular immunotherapies.

- Knowledge of haematopoiesis, immune-oncology, or tumour biology.

**Organizational and social skills**:

- Ability to design and execute computational research independently, with a strong emphasis on rigor and reproducibility

- High level of scientific curiosity and a commitment to understanding complex biological systems.

- Strong problem-solving and analytical skills.

- Excellent organizational abilities, with the capacity to manage multiple priorities and meet deadlines.

- Effective communication skills, with fluency in English.

- Collaborative mindset and willingness to contribute to interdisciplinary projects.

**Application Instructions

To apply, please send the following:

- a CV.

- a motivation letter in English relating your track record to the specifics of the call.

- names and contacts of 2 referees.

**Why Human Technopole**:

- HT seeks scientific excellence, we recruit the best scientific talents through international, open calls.

- Our working environment is international, friendly and inclusive.

Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.

- We believe that highly diverse teams yield the best and most innovative results.

- We engage in outward-facing scientific activities aimed at benefiting the national and international research community.

Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.

**Main benefits

- **Welfare plans.

- Canteen service.

- Work-life balance provisions.

- Italian language training for foreigners.

- Parental leave up to 1 year and other support for new parents.

- Counseling.

- Flexible working hours.

- Remote working policy.

- Support for relocation.

- Researchers coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits.

**Number of positions offered**: 1

**Contract offered**: CCNL Chimico Farmaceutico, 4 years fixed-term - Employee Level

**Starting date**:June 2025

**Salary range**: up to 40k

Tax benefits where applicable.

**The position is based in Milan.