Postdoc In Mechanisms Of Leukemogenesis – Giustacchini Group
APPLICATION CLOSING DATE: February 20th, 2025Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health.
HT is composed of five Centres: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science.
The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally. About the lab:Dr. Alice Giustacchini's research group combines experimental and computational biology in a collaborative environment at Human Technopole (HT), utilizing state-of-the-art technologies and interdisciplinary expertise.
The group collaborates closely with clinical teams at UCL and Ospedale Pediatrico Bambino Gesù, connecting basic science with clinical practice to ensure translational impact.
By addressing key challenges in hematologic malignancies, the group aims to drive advancements in precision medicine and develop innovative approaches to improve therapeutic outcomes. The Giustacchini group, based within the Population and Medical Genomics Centre at Human Technopole (HT), is searching for a postdoctoral researcher to investigate the molecular mechanisms of leukemogenesis in paediatric age. This project focuses on understanding the cellular and molecular pathways driving leukemic transformation during haematopoietic development.
The successful candidate will use in vitro differentiation systems (ESC/iPSC) to model normal and malignant haematopoiesis, exploring how developmental cues intersect with genetic lesions to initiate leukaemia.
Key additional methodologies will include CRISPR/Cas9-mediated gene editing, high-end flow cytometry, and single-cell multiomics.
The research will provide insights into the mechanisms underlying paediatric leukaemia and contribute to the development of novel therapeutic strategies. The successful candidate will work closely with a dynamic team of researchers and computational biologists within the Population and Medical Genomics Centre.
Clinical collaborations with teams at University College London and Ospedale Pediatrico Bambino Gesù will ensure translational relevance.
The role will also benefit from access to HT's state-of-the-art facilities, including the National Facilities for Genome Engineering and Disease Modelling, Genomics and Light Imaging. Key ResponsibilitiesDevelop and refine ESC/iPSC differentiation protocols to model leukemogenesis. Use CRISPR/Cas9-based genetic engineering to introduce and study the effects of leukaemia-associated mutations on hematopoietic stem/progenitor cell function. Conduct high-end flow cytometry for immunophenotyping, cell sorting, and functional characterization of hematopoietic and leukemic cell populations. Perform functional assays and integrate data from single-cell multiomics technologies to uncover molecular and cellular mechanisms of leukemic transformation. Collaborate with computational scientists to analyse high-dimensional data and generate mechanistic insights. Maintain accurate records of experimental results and actively contribute to manuscript preparation, publications, and presentations at international conferences. Participate in lab discussions, mentor junior team members, and contribute to collaborative projects. Job requirementsMandatory requirements:PhD in stem cell biology, haematology, molecular biology, or related disciplines. Extensive experience in hematopoietic stem/progenitor cell biology and developmental haematopoiesis. Proficiency in ESC/iPSC-based differentiation systems for modelling haematopoiesis. Expertise in CRISPR/Cas9-mediated gene editing and molecular biology techniques. Hands-on experience with high-end flow cytometry for immunophenotyping and cell sorting. Fluency in English – HT is an international research institute. Preferred requirements:Familiarity with single-cell multiomics technologies and analysis pipelines. Experience with 3D culture systems or organoid models to replicate hematopoietic microenvironments. Knowledge of clonal tracking methods to study cell fate and leukemic evolution. Organizational and social skills:Deep scientific curiosity and a commitment to understanding the mechanisms underlying leukemogenesis. Strong collaborative and communication skills, with the ability to contribute effectively to a multidisciplinary team. Excellent organizational and multitasking skills, with the ability to manage competing priorities. Proven ability to design and conduct complex experiments with a focus on reproducibility and scientific rigor. Application InstructionsTo apply, please send the following:a CV. a motivation letter in English relating your track record to the specifics of the call. names and contacts of 2 referees. Why Human Technopole:HT seeks scientific excellence; we recruit the best scientific talents through international, open calls.
Our working environment is international, friendly, and inclusive.
Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.
We believe that highly diverse teams yield the best and most innovative results.
We engage in outward-facing scientific activities aimed at benefiting the national and international research community.
Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences, and workshops. Main benefitsWelfare plans. Canteen service. Work-life balance provisions. Italian language training for foreigners. Parental leave up to 1 year and other support for new parents. Counselling. Flexible working hours. Remote working policy. Support for relocation. Researchers coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits. Special consideration will be given to candidates who are part of the protected categories list, according to L. 68/99. Number of positions offered: 1Salary: 40k eurosContract offered: CCNL Chimico Farmaceutico, Fixed-term 4 years - employee level. The position is based in Milan. The Foundation reserves the right, at its sole discretion, to extend, suspend, modify, revoke, or cancel this job posting without giving rise to any rights or claims whatsoever in favour of the candidates; the Foundation reserves, however, the right not to proceed with the awarding of the above-described assignment due to the effect of supervening regulatory provisions and/or obstructive circumstances.
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