Preclinical Development And Validation Of New Therapeutic Approaches For Motor Neuron Diseases. Bardi

Preclinical Development And Validation Of New Therapeutic Approaches For Motor Neuron Diseases.
Bardi
Emilia Romagna, Bardi

Organisation/Company: Università di Pavia Research Field: Neurosciences, Pharmacological sciences, Biological sciences Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 22 Jan 2025 - 23:59 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?

No Offer Description The project aims to validate new molecular targets to regulate neuroinflammatory and neuroprotective responses and assess a peripheral biomarker as an indicator of disease severity or treatment response.

A new platform of in vivo models will be developed to study motor neuron diseases, focusing on: In vitro assays to analyze the molecular mechanisms of neurodegeneration; In vivo experiments on disease models, including pharmacology studies to validate new therapeutic approaches and the predictivity of new pharmacodynamic biomarkers.

Advanced imaging techniques (MRI), ELISA analyses on biofluids, single-cell molecular profiling (single-cell RNAseq), and flow cytometry studies will be utilized.

The recruited individual will also support project accounting management, secretarial activities for communication between units, and project reporting coordination with the manager.

Main Requirements Degree (with a course duration of not less than 4 years) or post-graduate degrees awarded by recognized Italian or foreign Universities.

Scientific or professional curriculum suitable for conducting the research activity.

If available, any Ph. D. title.

Further Specific Assessable Qualifications Master's degree in a biological field and/or related fields; PhD (preferably enrolled in or completed a PhD program in a biological field or an equivalent qualification); Thesis on a topic related to the area of neurobiology with the application of key techniques for the project; Proven expertise in in vitro work (cell cultures) and the generation and manipulation of lentiviral vectors; Possession of certifications enabling preclinical in vivo experimentation on animal models with techniques relevant to the project's theme; Proven expertise in molecular biology and biochemistry techniques, flow cytometry and immunocytochemistry, and immunohistochemistry on histological preparations.

Selection Process The application for admission to the selection procedure (dated and signed), the documents and publications considered useful for the evaluation must be submitted electronically by visiting the following web page: https://pica. cineca. it/unipv.

Following the guidelines published in the procedure, the applicant must enter all the required information for the application, enclosing all documents in electronic. PDF format.

The selection of candidates is carried out on the basis of qualifications, project, and interview, supplemented by a test of knowledge of the foreign language.

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