Research Fellow At Human Inherited Neuropathies Unit Milano

Research Fellow At Human Inherited Neuropathies Unit
Milano
Lombardia, Milano

IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for two research fellows to join the Human Inherited Neuropathy Unit, led by Alessandra Bolino.

Research work in our laboratory integrates basic and clinical research through a translational approach.

Our research work is devoted to i) unravel the mechanisms at the basis of myelin formation and maintenance in the nerve and to ii) interfere with these mechanisms and pathways to ameliorate human diseases of the nervous system (for reference: Bolino et al. , Neurotherapeutics 2021).

further clarifying how lipid-mediated cytoskeleton remodeling and myelin synthesis control myelin growth in the nerve (Guerrero-Valero et al. , PNAS 2021);

decreasing PIKfyve lipid kinase activity to ameliorate aberrant myelin and fiber degeneration in inherited peripheral neuropathy models (Guerrero-Valero et al. , PNAS 2021; Sawade et al. , Nature Communications 2020).

**Main activities**:

Primary Schwann cells/Dorsal Root Ganglia neurons co-cultures;

Primary Schwann cell cultures;

Molecular biology;

Biochemical analyses from primary cells and tissues;

Immunohistochemistry and confocal microscopy on primary cultures and tissues;

Analyses of transcriptomics and proteomics datasets.

**Who we are looking for**:

Previous experience in laboratory research;

Research planning and organization skills.

**Work details**:

**Type of contract**: full time collaboration; salary will depend on research experience and CV of the applicant;

**Duration**: one year, renewable up to three years;

**Place of work**: IRCCS San Raffaele Scientific Institute, via Olgettina, 60 - Milan, Italy.