Role Of Smn2 Mrna Editing As Modulator Of The Clinical Severity Of Spinal Muscular Atrophy Lazio

Role Of Smn2 Mrna Editing As Modulator Of The Clinical Severity Of Spinal Muscular Atrophy
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Lazio, Lazio

Organisation/Company: Università Cattolica del Sacro CuoreResearch Field: Medical sciences » MedicineResearcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)Country: ItalyApplication Deadline: 15 Feb 2025 - 23:59 (UTC)Type of Contract: To be definedJob Status: Not ApplicableIs the job funded through the EU Research Framework Programme?

Other EU programmeIs the Job related to staff position within a Research Infrastructure?

NoOffer DescriptionmRNA editing is a physiologic process occurring in transcripts of some genes.

In the literature, some studies have shown the editing of the mRNA of some genes with specific function in the central nervous system, particularly in neuronal plasma membrane.

We have shown that SMN1 and SMN2 mRNA, responsible and modulator of the clinical severity of spinal muscular atrophy (SMA), respectively, undergo editing.

In the present project, we will define the role of SMN2 mRNA editing as a modulator of the phenotypic severity.

Additionally, we will try to identify the genes that are responsible for this process by developing cell models. Eligibility of fellows:Country/ies of residence: EUROPENationality/ies: #J-18808-Ljbffr