Study Of The Molecular And Anatomical Organisation Of Dopaminergic Circuits In Mouse Models Of [...] Lazio

Study Of The Molecular And Anatomical Organisation Of Dopaminergic Circuits In Mouse Models Of [...]
Roma
Lazio, Lazio

Organisation / Company: Università degli Studi di Torino

Research Field: Neurosciences

Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)

Country: Italy

Application Deadline: 27 Jan 2025 - 13:00 (UTC)

Type of Contract: To be defined

Job Status: Not Applicable

Funding: Not funded by a EU programme

Related to Research Infrastructure: No

Offer DescriptionCDKL5 deficiency syndrome (CDD) is a rare neurodevelopmental disorder belonging to the autism spectrum disorders.

Patients manifest intellectual disability and motor problems, suggesting possible dysfunction of the midbrain dopaminergic system.

As the impact of the loss of CDKL5 on this system is still poorly understood, the following project aims to study the dopaminergic system in mouse models of CDD (CDKL5-KO, CDKL5-E364X) by analysing (i) the morphological and molecular organisation of the synaptic contacts of the nigro-striatal circuits, (ii) the release of extracellular vesicles from cultured striatal neurons, (iii) and the role of striatal astrocytic glia, using cell biology and microscopy techniques.

Finally, a panel of behavioural tests will be performed to assess sensorimotor responses and locomotor capacity in these animals.

EligibilityCountry / ies of residence: All

Nationality / ies: All

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