Transcriptional Profiling Of Single Skeletal Muscle Mononucleated Cells Coupled With Broadband [...] Lazio

Transcriptional Profiling Of Single Skeletal Muscle Mononucleated Cells Coupled With Broadband [...]
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Organisation/Company: Università degli Studi di Padova Research Field: Biological sciences » Biology Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 17 Jan 2025 - 09:00 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?

No Offer Description Background: ME/CFS is a chronic disease affecting over 2 million people in Europe and America, characterized by persistent and unexplained post-exertional fatigue.

Its etiology and symptom heterogeneity remain unclear, and no single biomarker or definitive diagnostic sign has been identified.

Aim: The project addresses two key questions: a) What pathways are altered in the diverse cell populations of ME/CFS patient muscles?

b) How do cellular interactions and communication differ between patient and normal muscles?

Methods: The work will integrate impedance sensing, single-cell RNA sequencing, spatial transcriptomics, and pathway analysis to identify differential features, quantitatively explain alterations in ME/CFS patients, and discover new objective markers for diagnosis.

Collaborations: The researcher will work within an international group, collaborating with Lehigh University (USA), and the Universities of Chieti and Padova (Italy).

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