Transcriptional Profiling Of Single Skeletal Muscle Mononucleated Cells Coupled With Broadband [] Lazio

Transcriptional Profiling Of Single Skeletal Muscle Mononucleated Cells Coupled With Broadband []
Roma
Lazio, Lazio

Organisation / Company : Università degli Studi di Padova

Research Field : Biological sciences » Biology

Researcher Profile : Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)

Country : Italy

Application Deadline : 17 Jan 2025 - 09 : 00 (UTC)

Type of Contract : To be defined

Job Status : Not Applicable

Funding : Not funded by a EU programme

Research Position : Not related to staff position within a Research Infrastructure

Offer Description : Background : ME / CFS is a chronic disease affecting over 2 million people in Europe and America, characterized by persistent and unexplained post-exertional fatigue.

Its etiology and symptom heterogeneity remain unclear, and no single biomarker or definitive diagnostic sign has been identified.

Aim : The project addresses two key questions: a) What pathways are altered in the diverse cell populations of ME / CFS patient muscles?

b) How do cellular interactions and communication differ between patient and normal muscles?

Methods : The work will integrate impedance sensing, single-cell RNA sequencing, spatial transcriptomics, and pathway analysis to identify differential features, quantitatively explain alterations in ME / CFS patients, and discover new objective markers for diagnosis.

Collaborations : The researcher will work within an international group, collaborating with Lehigh University (USA), and the Universities of Chieti and Padova (Italy).

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